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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Free Radic Biol Med. 2012 Sep 26;53(11):2178–2187. doi: 10.1016/j.freeradbiomed.2012.09.028

Figure 3. Glucose metabolism is intimately linked to histone acetylation and deacetylation through cofactors.

Figure 3

The oxidation of glucose to pyruvate influences NAD+/NADH ratio in cells. Pyruvate from glycolysis is converted into acetyl-CoA via the mitochondria and TCA cycle. The Warburg effect, and the increased proliferation of cancer, are anticipated to change decrease the activities of sirtuins, and histone acetyltransferases. (* denotes that two molecules of each metabolite are being processed from this point on)