Table 2.

Clinical Characteristics of EI-AED Participants

Participant	Neurologic Diagnosis	EI-AED, Dose Daily	Serum EI-AED level (mcg/mL)	ARV regimen(s) during AED/ARV overlap	Serum ARV levels (ng/mL)¶	Seizure control during AED/ARV overlap
1	Status epilepticus secondary to Herpes Simplex Virus encephalitis	Carbamazepine 1,000 mg	9.1	Regimen 1: Nevirapine, Zidovudine, Didanosine	Nevirapine: 2,071*; 4,408	No
		Carbamazepine 1,000 mg	9.9	Regimen 2: Nevirapine, Zidovudine, Abacavir	Nevirapine: 3,231; 2,614*	Yes
2	Distal motor sensory neuropathy	Carbamazepine 600 mg	0.7	Efavirenz, Tenofovir, Lamivudine	Efavirenz: 1,379	Not applicable
3	Focal epilepsy with complex partial seizures	Phenytoin 500-550 mg	9	Regimen 1: Lopinavir, Ritonavir, Didanosine, Lamivudine	Lopinavir: 4,382; 4,360	Yes
		Phenytoin 500-550 mg	15	Regimen 2: Lopinavir. Ritonavir, Tenofovir, Lamivudine	Lopinavir: 976*; 2,858	Yes
4	Seizures secondary to progressive multifocal leukoencephalopathy	Phenytoin 600 mg	22.2; 20	Regimen 1: Efavirenz, Stavudine, Zalcitabine	Efavirenz: 187*; 307*	Yes
		Phenytoin 600 mg	19.3; 23	Regimen 2: Lopinavir, Ritonavir, Stavudine, Lamivudine	Lopinavir: 1,264	Yes
5	Seizure disorder, not otherwise specified	Phenytoin 300 mg	11.7	Efavirenz, Zidovudine, Lamivudine	Efavirenz: 200*; 7,556	Yes
6	Seizure disorder, not otherwise specified	Carbamazepine 1,000 mg	7.5	Regimen 1: Efavirenz, Stavudine, Didanosine	Efavirenz: 16,567; 13,610	No
		Carbamazepine 400 mg	6.1	Regimen 2: Efavirenz, Stavudine, Didanosine	Efavirenz: 11,861; 16,836	No
		Carbamazepine 400 mg	20	Regimen 3: Lopinavir, Ritonavir, Tenofovir, Lamivudine	Lopinavir: 1,072	No
7	Seizure disorder, not otherwise specified	Carbamazepine 800 mg	3.8	Lopinavir, Ritonavir, Tenofovir, Didanosine, Stavudine	Lopinavir: 3,369	Unknown
8	Seizure disorder, not otherwise specified	Phenytoin 600 mg	15.4	Lopinavir, Ritonavir, Didansine, Stavudine	Lopinavir: 515*; 145*	Unknown
9	Seizure disorder, not otherwise specified	Phenytoin 200-400 mg	3.4	Lopinavir, Ritonavir, Abacavir, Zidovudine, Lamivudine	Lopinavir: 4,890; 2,082	Unknown
		Phenytoin 200-400 mg	7.6	Lopinavir, Ritonavir, Abacavir, Zidovudine, Lamivudine	Lopinavir: 4,117; 5,810	Unknown
10	Trigeminal neuralgia	Carbamazepine 400 mg	3.1	Nevirapine,Tenofovir, Emtricitabine	Nevirapine: 3,469	Not applicable

EI-AED, enzyme-inducing antiepileptic drug; ARV, antiretroviral drug;

^¶Serum ARV level refers to efavirenz, nevirapine or lopinavir, as applicable.

^*ARV level below minimum recommended level (C_min) for the drug