Table 3.
Frequency of Serum ARV Levels Below Cmin for the EI-AED Group Compared to the NEI-AED Group
ARV levels below Cmin (analysis based on all AED/ARV overlap intervals) | EI-AED Group n (%) | NEI-AED Group n (%) | P-value |
---|---|---|---|
None | 10 (62.5) | 23 (76.7) | 0.124 |
One level below Cmin | 4 (25) | 7 (23.3) | |
Two levels below Cmin | 2 (12.5) | 0 (0) | |
ARV levels below Cmin (analysis after exclusion of intervals with EI-AED levels below reference range) | |||
None | 4 (40) | 23 (76.7) | 0.008 |
One Level below Cmin | 4 (40) | 7 (23.3) | |
Two Levels below Cmin | 2 (20) | 0 (0) |
ARV, antiretroviral drug; Cmin, minimum recommended serum concentration; EI-AED, enzyme-inducing antiepileptic drug; n, number of AED/ARV overlaps; NEI-AED, non enzyme-inducing antiepileptic drug