Table 4.
Frequency of Serum ARV Levels According to Co-administered AED
| EI-AED Group | NEI-AED Group | |||||
|---|---|---|---|---|---|---|
| Carbamazepine | Phenytoin | Gabapentin | ||||
| ARVs | ARV level below Cmin (n, %) | ARV level above Cmin (n, %) | ARV level below Cmin (n, %) | ARV level above Cmin (n, %) | ARV level below Cmin (n, %) | ARV level above Cmin (n, %) |
| NNRTIs | ||||||
| Efavirenz | 0 (0) | 5 (100) | 3 (75) | 1 (25) | 1 (4.3) | 22 (95.7) |
| Nevirapine | 2 (40) | 3 (60) | N/A | N/A | 1 (16.7) | 5 (83.3) |
| PIs | ||||||
| Lopinavir | 2 (50) | 2 (50) | 1 (11.1) | 8 (88.9) | 5 (22.7) | 17 (77.3) |
EI-AED, enzyme-inducing antiepileptic drug; NEI-AED, non enzyme-inducing antiepileptic drug; ARVs, antiretroviral drugs; Cmin, minimum recommended serum concentration; NNRTIs, non-nucleotide reverse transcriptase inhibitors; PIs, protease inhibitors