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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2012 Oct 23;265(2):181–189. doi: 10.1016/j.taap.2012.10.009

Figure 5. Anti-streptococcal serum antibody production was markedly altered by prenatal exposure to Cd.

Figure 5

Twenty week-old mice that were exposed to 10 ppm Cd (solid bars) or water (open bars) in utero were immunized with heat-killed S. pneumoniae vaccine. Sera were collected 10 days after immunization to determine anti-PC and anti-PspA antibody titers in males and females. Antibody levels were determined by ELISA as described in the Materials and Methods. A) The serum anti-PC antibody titers of the male offspring; B) the serum anti-PC antibody titers of the female offspring; C) the serum anti-PspA antibody titers of the male offspring; D) the serum anti-PspA antibody titers of the female offspring. Each bar represents the mean ± SEM. Data are representative of 2 experiments where the n equals at least 5 in each group. *p<0.05