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Blood clearance and biodistribution of polydisulfide DNCs and PAMAM(G3)-[Gd-C-DOTA]-1. Polydisulfide DNCs (59 nm) and PAMAM(G3)-[Gd-C-DOTA]-1(3.6 nm) were administered intravenously into nu/nu mice (n=3 each). (A) Blood samples were collected at various time points post-injection and analyzed for Gd content via ICP MS. (B) Mice were sacrificed 24 h following the administration of contrast agents and select organs were harvested and also analyzed for Gd content.
