Figure 1.

Scheme for the TRPC signaling pathway in hypertrophy. Stimulation of Gq-protein coupled receptors (GPCR) and subsequent activation of PLC leads to IP₃ and DAG generation. DAG directly activates TRPCs and induces receptor-operated Ca²⁺ entry (ROCE), causing membrane depolarization and secondarily activating LTCCs. IP₃ activates IP₃Rs, which induce depletion of stores and activation of STIM. STIM1 provokes store-operated Ca²⁺ entry (SOCE) through Orai and/or TRPCs. TRPC channels can also be activated by stretch (SAC). The increase in intracellular Ca²⁺ following TRPC activation is involved in hypertrophy development via activation of the calcineurin-NFAT pathway.