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. 2012 Nov 28;2:896. doi: 10.1038/srep00896

Figure 5. Resatorvid reduced neuronal cell death after cerebral ischemia.

Figure 5

(A) Representative photographs showing immunolabels for the apoptosis marker cleaved caspase-3, the neuronal marker NeuN, and the nuclear marker Hoechst33342 in the cortical peri-infarct region of sham-operated, vehicle-treated, and resatorvid-treated mice. (B) Quantitative analysis of neuronal apoptosis at 24 h after MCAO. Cleaved caspase-3-positive neuronal cells were increased by 2 h of ischemia plus 22 h of reperfusion. Treatment of mice with resatorvid (at 0.01 μg, i.c.v.) partly prevented the neuronal apoptosis. Scale bar = 20 μm. ## P < 0.01 vs. sham, ** P < 0.01 vs. vehicle, n = 5. Statistical significance was evaluated with Student unpaired, two-tailed t-test.