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. Author manuscript; available in PMC: 2012 Nov 28.
Published in final edited form as: Prog Mol Biol Transl Sci. 2011;98:401–443. doi: 10.1016/B978-0-12-385506-0.00010-7

TABLE II.

Role of 5-HT Receptors in the Attenuation of Alcohol Consumption

Type of 5-HT receptors Effect of selective 5-HT receptor agonist or antagonist in animal model in alcohol intake Effect of selective 5-HT receptor agonist or antagonist in clinics in alcohol consumption References
5-HT1A receptors Agonists, 8-OH-DPAT, buspirone, and NDO-008 reduced alcohol intake in Wistar rats Partial agonist, buspirone, reduced depressive state and the number of days in desire to drink alcohol 179-181,308,310
5-HT1B receptors Agonists, CP-94253, mCPP, and CGS-12066B reduced alcohol intake in Wistar rats Not determined 142,145,158,294
5-HT3 receptors Antagonists reduced alcohol intake in rats Antagonist, ondansetron, reduced alcohol intake in type B but not type A alcoholics 94,182,294,297,300,301