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. Author manuscript; available in PMC: 2013 Nov 21.
Published in final edited form as: Chem Biol. 2012 Nov 21;19(11):1460–1470. doi: 10.1016/j.chembiol.2012.09.017

Figure 3. OADS is a selective CLC inhibitor.

Figure 3

A) Representative current families from inside-out patches excised from Xenopus oocytes expressing human ClC-1. Currents before (left), and after (right) steady-state inhibition in 30 μM OADS were elicited by the voltage protocol shown below the traces.

B) ClC-1 currents as in (A) but with 30 μM cis-OADS.

C) Summary data comparing inhibition of ClC-1 by OADS and cis-OADS (left) to inhibition of ClC-ec1 by OADS and cis-OADS (right). ClC-ec1 was reconstituted in PE/PG liposomes and measured in Cl− efflux assays. For each experiment, data represent the mean ± SEM for 3 experiments.