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Schematic diagrams for summarizing the different methods available to identify proviral insertion sites. (A)Methods requiring restriction enzyme digestion adjacent to insertion sites, including inverse PCR, LM-PCR, LAM-PCR and multi-arm optimized LAMPCR. (B) Methods without restriction enzyme digestion, including FLEA-PCR, nrLAM-PCR and transposase MuA based-PCR. (Timeline shows the year when each method was first described.)
