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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Cancer Discov. 2012 Oct 5;2(11):985–994. doi: 10.1158/2159-8290.CD-12-0178

Figure 5. Non-invasively measuring MYC signaling with a radiotracer targeting TFRC.

Figure 5

A schematic representation of the relationship between MYC activity and TFRC expression, and the strategy to exploit this relationship for PET imaging. TFRC is a validated MYC target gene in many cancers, including prostate cancer. The soluble ligand of TFRC, the serum protein transferrin (Tf), was radiolabeled to target the relative changes in TFRC expression that occur with fluctuations in MYC signaling.