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. 2012 Nov 9;4:383–395. doi: 10.2147/CMAR.S38022

Figure 2.

Figure 2

Nontoxic doses of selenite enhance growth inhibition and inhibit DNA synthesis in PC-3 cells sensitized with carmustine. PC-3 cells were pretreated with 10 or 20 μM carmustine for 30 minutes and then treated with different concentrations of selenite (0.5–5 μM) for 96 hours. (A) Cell growth and (B) DNA synthesis were then determined as described in the Materials and methods section. The data are presented as the mean ± standard deviation. (*P < 0.05; n = 3) and expressed as optical density at 550 nm for cell growth; optical density at 405 nm for DNA synthesis. Data are normalized to the control. Comparisons shown: (a) significant compared with control; (b) significant compared with 1.5 μM selenite-treated cells; (c) significant compared with 2.5 μM selenite-treated cells.