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. 2012 Nov 9;5:935–942. doi: 10.2147/IJGM.S30570

Figure 5.

Figure 5

Characteristic LTP responses are observed in the MPP under isoflurane anesthesia. A plot of normalized field excitatory postsynaptic potential (fEPSP) slope magnitude of medial perforant path-CA3 responses over time using current intensities eliciting 50% of the maximal response and the percent change in amplitude (mean ± SEM).

Notes: Blue diamonds: MPP LTP is induced in the presence of Ringer’s solution in isoflurane (+66% ± 45%, n = 4) anesthetized animals. Green squares: LTP induction is blocked in the presence of 3-[(R)-2-carboxypiperazin-4-yl]-propo-2-enyl-1-phosphonic acid (CPP; 3 nmol ic; +3% ± 15%, n = 4).

Abbreviations: MPP, 1-methyl-4-phenylpyridine; LTP, long-term potentiation; HFS, high frequency stimulation; CA3, cornu ammonis region 3; SEM, standard error of the mean.