Table 1.

MYCN status and aberrations in the p53/MDM2/p14^ARF pathway in neuroblastoma cell lines.

Cell Line	MYCN Status	p53 Mut	p53 Mut Codon	MDM2 Amp	p14ARF Deln	p14ARF Meth	Diagnosis/ Relapse§	Reference
ACN	nMNA	Yes	113				Relapse	Forbes et al. (2008)
CHLA-119	MNA1	Yes	342				Relapse	Keshelava et al. (2001)
CHLA-172	nMNA1	Yes	216				Relapse	Keshelava et al. (2001)
CHLA-90	nMNA	Yes	286				Relapse	Keshelava et al. (2001)
CLB-Pe	MNA	Yes	176				Relapse	Mergui et al. (2008)
IGRN91	MNA	Yes	a				Relapse	Goldschneider et al. (2004, 2006)
IGR-NB8	MNA	Yes	326				Diagnosis	Goldschneider et al. (2006)
KELLY/N-206	MNA	Yes	177				Unknown	Mergui et al. (2008), Van Maerken et al. (2011)
KP-N-YS	MNA	Yes	135				Diagnosis2	Forbes et al. (2008)
LAN-1	MNA	Yes	182				Relapse	Davidoff et al. (1992), Van Maerken et al. (2011)
LAN-2	MNA	Yes	337				Diagnosis	Van Maerken et al. (2011)
NB4	MNA	Yes	173				Diagnosis3	Teitz et al. (2002)
NB6	MNA	Yes	282				Relapse	Teitz et al. (2002)
NB8	MNA	Yes	b				Diagnosis	Teitz et al. (2002), Van Maerken et al. (2011)
NB12	MNA	Yes	173				Unknown	Teitz et al. (2002)
NB13	MNA	Yes	173				Unknown	Teitz et al. (2002)
NB14	MNA	Yes	c				Diagnosis	Teitz et al. (2002)
NB15	MNA	Yes	248				Unknown	Teitz et al. (2002)
NB20	MNA	Yes	248				Unknown	Teitz et al. (2002)
NLF	MNA	Yes	203				Diagnosis4	Van Maerken et al. (2011)
NMB	MNA	Yes	245				Relapse	Goldman et al. (1996)
SJNB-4	MNA	Yes	176				Relapse	McPake et al. (1998)
SKNAS	nMNA	Yes	d				Relapse	Goldschneider et al. (2006), Nakamura et al. (2007), Van Maerken et al. (2011)
SKNBE2C	MNA	Yes	135				Relapse	Kaghad et al. (1997), Keshelava et al. (2001), Tweddle et al. (2001a,b) Van Maerken et al. (2011)
SK-N-DZ	MNA	Yes	110				Relapse5	Forbes et al. (2008)
SK-N-FI	nMNA	Yes	246				Relapse	Van Maerken et al. (2006, 2011)
TGW	MNA	Yes	282				Relapse	Sugiyama et al. (2003)
NGP	MNA			Yes			Relapse	Corvi et al. (1995), Tweddle et al. (2001b), Van Maerken et al. (2011)
NB1691	MNA			Yes			Relapse	McKenzie et al. (1999)
CHLA134	MNA			Yes			Relapse	Keshelava et al. (2001)
LS	MNA			Yes			Relapse	Corvi et al. (1995), Carr et al. (2006)
TR-14	MNA			Yes			Relapse	Carr et al. (2006), Van Maerken et al. (2011)
LAN-6	nMNA				Yes		Relapse	Keshelava et al. (2001), Thompson et al. (2001), Van Maerken et al. (2011)
SHEP	nMNA				Yes		Relapse	Tweddle et al. (2001b), Carr et al. (2006), Van Maerken et al. (2011)
CHLA-101	MNA				Yes e		Relapse	Thompson et al. (2001)
CHLA-174	nMNA				Yes		Relapse	Thompson et al. (2001)
CHLA-179	MNA				Yes		Relapse	Thompson et al. (2001)
STA-NB-3	MNA				Yes		Relapse6	Van Maerken et al. (2011)
GIMEN	nMNA					Yes	Relapse	Carr et al. (2006)
PER-108	MNA					Yes	Relapse	Carr et al. (2006)

Mut, mutation; Amp, amplification; Deln, deletion; Meth, methylation; MNA, MYCN amplified; nMNA, non-MYCN amplified.

^§Any cell line established prior to chemo/radiotherapy was classified as established at diagnosis and any cell lines established post-treatment was classified as established at relapse.

¹Personal communication with P. Reynolds, ²Personal communication with T. Sugimoto, ³Personal communication with S. Ragsdale, ⁴Personal communication with G. Brodeur, ⁵Personal communication with L. Helson, ⁶Personal communication with P. Ambros.

^aDuplication of exons 7–9 between exons 9 and 10 resulting in an extra ~321nts, ^bDeletion of codons 105-125, ^cDeletion of codons 126–132, ^dDeletion of exons 10 and 11 resulting in truncated product ~369nts, ^e104 bp deletion.