Table 3.
Genotype and allelic frequency distribution among 300 healthy individuals and the total cohorts of Crohn’s disease and ulcerative colitis
| GG-genotype (%) | GC-genotype (%) | CC-genotype (%) | G-allele (%) | C-allele (%) | |
| Healthy | |||||
| ECP562 | 68 | 29 | 3 | 83 | 17 |
| ECP434 | 57 | 38 | 5 | 76 | 24 |
| EPX405 M1 | 64 | 32 | 4 | 80 | 20 |
| EPX405 F1 | 53 | 38 | 9 | 72 | 28 |
| CD | |||||
| ECP562 | 64 | 33 | 4 | 80 | 20 |
| ECP434 | 53 | 40 | 7 | 73 | 27 |
| EPX405 M | 55 | 38 | 6 | 74 | 26 |
| EPX405 F | 58 | 34 | 8 | 75 | 25 |
| UC | |||||
| ECP562 | 64 | 33 | 4 | 80 | 20 |
| ECP434 | 55 | 38 | 7 | 74 | 26 |
| EPX405 M | 62 | 31 | 7 | 78 | 22 |
| EPX405 F | 57 | 38 | 5 | 76 | 24 |
For ECP434 and ECP562 there was no difference between males and females.
1
In EPX405 there was a difference between the sexes according their genotype (P = 0.049) and allelic distribution (P = 0.021). UC: Ulcerative colitis; CD: Crohn’s disease; EPX: Eosinophil protein X; ECP: Eosinophil cationic protein; F: Female; M: Male.