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. Author manuscript; available in PMC: 2012 Nov 28.
Published in final edited form as: Trends Biochem Sci. 2012 Apr 3;37(5):179–188. doi: 10.1016/j.tibs.2012.02.009

Figure 5.

Figure 5

Microarray analysis of pre-mRNA splicing in yeast and the effects of mutations in core spliceosomal proteins. Each pre-mRNA in yeast (such as the subset of 12 shown here) can respond uniquely to mutations in core splicing factors. These responses can be identified by either increases (yellow bands) or decreases (blue bands) in pre-mRNA abundance relative to a wild type strain. This indicates that pre-mRNA identity can strongly influence multiple steps in splicing. Data are from reference [53] and used with the authors’ permission.

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