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Knockdown of aldehyde dehydrogenase 1A1 (ALDH1A1) confers sensitivity to gemcitabine (GEM). An MTT assay of MIA PaCa-2 cells transfected with ALDH1A1-siRNA or control-siRNA for 48 h and further treated with GEM in a dose-dependent manner (0, 0.01, 0.1, 1 and/or 10 μM) for 72 h was used to determine cell viability. Error bars represent standard deviation. **P<0.01 represents significant difference between the ALDH1A1-siRNA plus GEM and control-siRNA plus GEM groups.
