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. Author manuscript; available in PMC: 2012 Nov 28.
Published in final edited form as: AIDS. 2011 Sep 24;25(15):1833–1841. doi: 10.1097/QAD.0b013e32834a1d94

Figure 4.

Figure 4

SHIV-specific CD4+ and CD8+ T cell response in macaques with combined treatment prior to and following virus exposure. The percentages of CD4+ and CD8+ T cells producing IFN-γ and IL-2 in response to SIV Gag were determined by intracellular cytokine staining. Cytokine profiles of CD4+ and CD8+ T cells in the fifteen combination-treated macaques at 2 weeks after rAd5 boost (A), and at 1–2 weeks after first vaginal challenge with SHIVSF162P3 (B) are shown. The fifteen macaques are listed in the order of increasing time to infection, and grouped according to their infection status as well as the virus dose required to establish systemic infection.