Table II.

Comparison of RISE and HEIRS HFE genotypes in first time and repeat donors, stratified by race

	Wild Type or Missing n (%)	Heterozygous H63D n (%)	Heterozygous C282Y n (%)	Homozygous H63D n (%)	Homozygous C282Y n (%)	Double Mutation n (%)	Total
All Donors
RISE Study*	1,571 (64.8)	573 (23.6)	194 (8.0)	39 (1.6)	7 (0.3)	41 (1.7)	2,425
FT/Reactivated	592 (66.7)	210 (23.7)	60 (6.8)	10 (1.1)	3 (0.3)	13 (1.5)	888
Frequent/Repeat	979 (63.7)	363 (23.6)	134 (8.7)	29 (1.9)	4 (0.3)	28 (1.8)	1,537
HEIRS Study	73,066 (76.0)	15,326 (15.9)	5,207 (5.4)	1,242 (1.3)	292 (0.3)	991 (1.0)	96,124
Asian Donors
RISE: FT/Reactivated	42 (93.3)	2 (4.5)	1 (2.2)	0	0	0	45
RISE: Frequent/Repeat	31 (100.0)	0	0	0	0	0	31
HEIRS Study	11,657 (91.3)	1,070 (8.4)	16 (0.1)	29 (0.2)	0	0	12,772
Black Donors
RISE: FT/Reactivated	49 (92.4)	2 (3.8)	2	0	0	0	53
RISE: Frequent/Repeat	53 (84.1)	10 (15.9)	0	0	0	0	63
HEIRS Study	24,930 (91.9)	1,520 (5.6)	608 (2.2)	30 (0.1)	4 (0.0)	35 (0.1)	27,127
Hispanic Donors
RISE: FT/Reactivated	27 (67.5)	12 (30.0)	0	0	0	1 (2.5)	40
RISE: Frequent/Repeat	22 (61.1)	11 (30.5)	2 (5.6)	0	0	1 (2.8)	36
HEIRS Study	9,700 (79.9)	2,199 (18.1)	35 (0.3)	154 (1.3)	7 (0.1)	48 (0.4)	12,143
White Donors
RISE: FT/Reactivated	451 (62.6)	188 (26.1)	57 (7.9)	10 (1.4)	3 (0.4)	11 (1.5)	720
RISE: Frequent/Repeat	859 (61.8)	340 (24.4)	132 (9.5)	29 (2.1)	4 (0.3)	27 (1.9)	1,391
HEIRS Study	26,779 (60.8)	10,537 (23.9)	4,548 (10.3)	1,029 (2.3)	281 (0.6)	908 (2.1)	44,082

^*29 RISE donors report their Racial/Ethnic group as “Other” and 17 are missing Race/Ethnicity (and not presented in this table); 3 are missing HFE genotype (and are pooled with WT).

RISE, Retrovirus Epidemiology Donor Study-II (REDS-II) donor Iron Status Evaluation; HEIRS, Haemochromatosis and Iron Overload Screening; FT, first time donor