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LRP1 deletion in vascular smooth muscle cells does not affect the expression levels of major Aβ-degrading enzymes. The mRNA levels of neprilysin (A), IDE (B), MMP2 (C), and MMP9 (D) in the cortex from control and smLrp1−/− mice were quantified by RT-PCR at the age of 12 months. Data are plotted as mean ± SEM (n = 6). N.S., Not significant.
