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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Clin Exp Allergy. 2012 Dec;42(12):1791–1800. doi: 10.1111/j.1365-2222.2012.04043.x

Figure 1.

Figure 1

Absorption of OVA-specific maternal antibodies was dependent on offspring FcRn. Serum concentrations of OVA-specific IgG1 or IgE antibodies in (A) allergic foster mothers and (B) FcRn+/+, FcRn+/−, or FcRn−/− breastfed offspring are shown. Serum concentrations of OVA-specific IgG1 were significantly lower in FcRn−/− offspring when compared to FcRn+/+ or FcRn+/− offspring. OVA-specific IgE was detected in the serum of FcRn+/+ and FcRn+/− offspring, but not in the serum of FcRn−/− offspring. Similar results were obtained in 2 additional experiments. *** P < 0.001.