Skip to main content
. Author manuscript; available in PMC: 2012 Nov 28.
Published in final edited form as: J Urol. 2011 Nov 17;187(1):302–309. doi: 10.1016/j.juro.2011.09.010

Table 3.

Dose toxicity profile of 14d 5-azaC cohort

Grade
Dose (event) (mg/kg) No. Dogs 1 2 3 4
Hematological
0.20: 3
   Neutropenia 0 0 0 1*
   Thrombocytopenia 1 0 0 0
0.15: 2
   Neutropenia 0 1 0 0
   Thrombocytopenia 1 0 0 0
0.10 (neutropenia) 6 1 2 1† 0
Nonhematological
0.20: 3
   Nausea 3 0 0 0
   Anorexia 1 0 0 0
   Hand-foot 1 0 0 0
    syndrome
0.15: 2
   Diarrhea 1 0 0 0
   Anorexia 1 0 0 0
0.10:
   Nausea 2 0 0 0
   Anorexia 3 1 2† 0
*

During cycles 1 and 2.

†

After cycle 2.