Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Figure 2. Positive regulatory mechanisms of TRPC4 and TRPC5 channels. TRPC4 and TRPC5 channels are activated by many signals. Extracellular chemical signals, such as the GPCR agonist, lipids, metal ions, EGF and NO, activate TRPC4 and TRPC5 channels directly via Gi/o proteins, calcium, CaM, nitrosylation and PIP2 or indirectly via store depletion and exocytosis.
