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Figure 3. Negative regulatory mechanisms of TRPC4 and TRPC5 channels. Phosphorylation of TRPC4 and TRPC5 channels by PKA and PKC works as an inactivation pathway of TRPC4 and TRPC5 channels. On the other hand, PtdIns(4,5)P2 hydrolysis negatively regulates TRPC4 and TRPC5.
