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Figure 5. The schematic diagram for GPCR-mediated regulation of TRPC4 and TRPC5 channels. TRPC4 and TRPC5 channels may exist as a signal complex at caveolae that consists of GPCR (M2, M3 receptor alone or heteromultimer), the Gi/o protein, the Gq protein, PLC, PtdIns(4,5)P2 SESTD1 and RGS.
