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. 2012 Sep 1;6(5):370–378. doi: 10.4161/chan.21947

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Copyright © 2012 Landes Bioscience

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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graphic file with name chan-6-370-g3.jpg — Figure 3. Effect of the Lck-STIM1-C construct on CRAC channel activity in RBL cells. (A) Mean (± SE) store-operated CRAC channel currents measured at -80 mV in untransfected cells (untran), in cells expressing a control siRNA (cont siRNA), a STIM1 siRNA (siRNA) and in the same STIM1 siRNA-treated cells expressing an siRNA-resistant wild-type STIM1 (siRNA⁺WT) or an siRNA-resistant Lck-STIM1-C construct (siRNA⁺Lck). (B) Mean (± SE) I/V curves for CRAC channels in untransfected RBL cells (black), in STIM1 siRNA-treated cells (open circles) and in the same cells expressing the siRNA-resistant Lck-STIM1-C construct (gray circles). (C) Representative live confocal image of RBL cells expressing the Lck-STIM1-CT construct bearing a C-terminal eGFP-tag.