Table 5.
Correlation between genotypes or alleles and serum lipid levels in the total population
| Lipid | Genotype/allele | Unstandardized coefficient | Std. error | Standardized coefficient | t | P |
|---|---|---|---|---|---|---|
| TC |
ACAT-1 rs1044925 genotype |
−0.099 |
0.043 |
−0.053 |
−2.287 |
0.022 |
| |
LIPC -250G>A allele |
0.101 |
0.046 |
0.050 |
2.170 |
0.030 |
| |
LIPG 584C>T genotype |
0.149 |
0.043 |
0.079 |
3.503 |
0.000 |
| |
LIPG 584C>T allele |
0.169 |
0.049 |
0.077 |
3.425 |
0.001 |
| |
MTHFR 677C>T genotype |
0.218 |
0.037 |
0.133 |
5.854 |
0.000 |
| |
MTHFR 677C>T allele |
0.269 |
0.046 |
0.133 |
5.841 |
0.000 |
| |
PPARD +294T>C allele |
0.147 |
0.050 |
0.068 |
2.963 |
0.003 |
| TG |
MTHFR 677C>T genotype |
0.146 |
0.054 |
0.062 |
2.701 |
0.007 |
| |
MYLIP rs3757354 genotype |
−0.102 |
0.042 |
−0.057 |
−2.456 |
0.014 |
| |
PPARD +294T>C allele |
0.321 |
0.086 |
0.087 |
3.732 |
0.000 |
| |
SCARB1 rs5888 genotype |
−0.041 |
0.023 |
−0.049 |
−2.039 |
0.042 |
| HDL-C |
ACAT-1 rs1044925 genotype |
−0.057 |
0.022 |
−0.062 |
−2.643 |
0.008 |
| |
ACAT-1 rs1044925 allele |
−0.051 |
0.025 |
−0.048 |
−2.024 |
0.043 |
| |
LIPC -250G>A genotype |
0.038 |
0.016 |
0.055 |
2.366 |
0.018 |
| |
LIPG 584C>T genotype |
0.086 |
0.018 |
0.108 |
4.667 |
0.000 |
| |
LIPG 584C>T allele |
0.080 |
0.021 |
0.087 |
3.762 |
0.000 |
| |
MTHFR 677C>T genotype |
0.097 |
0.017 |
0.132 |
5.718 |
0.000 |
| |
MTHFR 677C>T allele |
0.123 |
0.021 |
0.136 |
5.868 |
0.000 |
| |
MYLIP rs3757354 genotype |
0.036 |
0.015 |
0.058 |
2.465 |
0.014 |
| LDL-C |
ABCA-1 V825I genotype |
0.075 |
0.025 |
0.068 |
2.954 |
0.003 |
| |
MTHFR 677C>T genotype |
0.075 |
0.029 |
0.059 |
2.562 |
0.010 |
| |
MTHFR 677C>T allele |
0.120 |
0.036 |
0.077 |
3.334 |
0.001 |
| ApoA1 |
ACAT-1 rs1044925 genotype |
−0.042 |
0.013 |
−0.074 |
−3.143 |
0.002 |
| |
ACAT-1 rs1044925 allele |
−0.042 |
0.016 |
−0.063 |
−2.672 |
0.008 |
| |
LIPC -250G>A genotype |
0.036 |
0.012 |
0.068 |
3.020 |
0.003 |
| |
LIPG 584C>T genotype |
0.040 |
0.012 |
0.076 |
3.303 |
0.001 |
| |
LIPG 584C>T allele |
0.039 |
0.014 |
0.064 |
2.781 |
0.005 |
| |
MTHFR 677C>T genotype |
0.053 |
0.010 |
0.118 |
5.130 |
0.000 |
| |
MTHFR 677C>T allele |
0.068 |
0.013 |
0.123 |
5.338 |
0.000 |
| ApoB |
MTHFR 677C>T genotype |
0.032 |
0.008 |
0.086 |
3.781 |
0.000 |
| |
MTHFR 677C>T allele |
0.042 |
0.010 |
0.092 |
4.049 |
0.000 |
| ApoA1/ApoB | LIPC -250G>A genotype | 0.070 | 0.026 | 0.063 | 2.649 | 0.008 |
TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B; ABCA-1, ATP-binding cassette transporter A1; ACAT-1, acyl-CoA:cholesterol acyltransferase-1; LDL-R, low density lipoprotein receptor; LIPC, hepatic lipase gene; LIPG, endothelial lipase gene; MTHFR, methylenetetrahydrofolate reductase; MYLIP, the E3 ubiquitin ligase myosin regulatory light chain-interacting protein; PCSK9, proprotein convertase subtilisin-like kexin type 9; PPARD, peroxisome proliferator-activated receptor delta; SCARB1, Scavenger receptor class B type 1.