Table 6.
Correlation between genotypes or alleles and serum lipid levels in the normal weight subjects
| Lipid | Genotype/allele | Unstandardized coefficient | Std. error | Standardized coefficient | t | P |
|---|---|---|---|---|---|---|
| TC |
ACAT-1 rs1044925 genotype |
−0.131 |
0.053 |
−0.078 |
−2.477 |
0.013 |
| |
LDL-R AvaII genotype |
−0.089 |
0.043 |
−0.062 |
−2.049 |
0.041 |
| |
LDL-R AvaII allele |
−0.121 |
0.056 |
−0.066 |
−2.178 |
0.030 |
| |
LIPC -250G>A genotype |
0.156 |
0.045 |
0.106 |
3.443 |
0.001 |
| |
LIPC -250G>A allele |
0.204 |
0.057 |
0.111 |
3.593 |
0.000 |
| |
MTHFR 677C>T genotype |
0.266 |
0.046 |
0.179 |
5.768 |
0.000 |
| |
MTHFR 677C>T allele |
0.290 |
0.057 |
0.158 |
5.089 |
0.000 |
| |
PPARD +294T>C genotype |
0.101 |
0.048 |
0.066 |
2.104 |
0.036 |
| TG |
LIPC -250G>A allele |
0.149 |
0.065 |
0.072 |
2.292 |
0.022 |
| |
MYLIP rs3757354 genotype |
−0.101 |
0.045 |
−0.071 |
−2.251 |
0.025 |
| |
SCARB1 rs5888 genotype |
−0.142 |
0.066 |
−0.068 |
−2.157 |
0.031 |
| HDL-C |
ACAT-1 rs1044925 genotype |
−0.061 |
0.028 |
−0.068 |
−2.177 |
0.030 |
| |
LIPC -250G>A genotype |
0.045 |
0.022 |
0.062 |
2.040 |
0.042 |
| |
LIPG 584C>T genotype |
0.085 |
0.025 |
0.104 |
3.364 |
0.001 |
| |
LIPG 584C>T allele |
0.085 |
0.030 |
0.089 |
2.877 |
0.004 |
| |
MTHFR 677C>T genotype |
0.105 |
0.024 |
0.134 |
4.361 |
0.000 |
| |
MTHFR 677C>T allele |
0.129 |
0.030 |
0.134 |
4.352 |
0.000 |
| |
MYLIP rs3757354 genotype |
0.054 |
0.021 |
0.082 |
2.609 |
0.009 |
| LDL-C |
LIPC -250G>A genotype |
0.080 |
0.037 |
0.067 |
2.171 |
0.030 |
| |
LIPC -250G>A allele |
0.125 |
0.046 |
0.084 |
2.713 |
0.007 |
| |
MTHFR 677C>T genotype |
0.146 |
0.036 |
0.126 |
4.016 |
0.000 |
| |
MTHFR 677C>T allele |
0.156 |
0.045 |
0.109 |
3.493 |
0.000 |
| ApoA1 |
ACAT-1 rs1044925 genotype |
−0.047 |
0.018 |
−0.080 |
−2.606 |
0.009 |
| |
LIPC -250G>A genotype |
0.048 |
0.016 |
0.087 |
2.969 |
0.003 |
| |
LIPC -250G>A allele |
0.051 |
0.020 |
0.074 |
2.516 |
0.012 |
| |
LIPG 584C>T genotype |
0.040 |
0.016 |
0.075 |
2.467 |
0.014 |
| |
LIPG 584C>T allele |
0.049 |
0.019 |
0.079 |
2.608 |
0.009 |
| |
MTHFR 677C>T genotype |
0.057 |
0.014 |
0.121 |
3.965 |
0.000 |
| |
MTHFR 677C>T allele |
0.071 |
0.018 |
0.122 |
4.019 |
0.000 |
| |
SCARB1 rs5888 genotype |
−0.034 |
0.012 |
−0.065 |
−2.742 |
0.006 |
| ApoB |
LIPC -250G>A allele |
0.033 |
0.013 |
0.078 |
2.498 |
0.013 |
| |
MTHFR 677C>T genotype |
0.037 |
0.011 |
0.105 |
3.359 |
0.001 |
| |
MTHFR 677C>T allele |
0.039 |
0.013 |
0.091 |
2.904 |
0.004 |
| SCARB1 rs5888 allele | −0.012 | 0.010 | −0.048 | −2.043 | 0.041 |
TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B; ABCA-1, ATP-binding cassette transporter A1; ACAT-1, acyl-CoA:cholesterol acyltransferase-1; LDL-R, low density lipoprotein receptor; LIPC, hepatic lipase gene; LIPG, endothelial lipase gene; MTHFR, methylenetetrahydrofolate reductase; MYLIP, the E3 ubiquitin ligase myosin regulatory light chain-interacting protein; PCSK9, proprotein convertase subtilisin-like kexin type 9; PPARD, peroxisome proliferator-activated receptor delta; SCARB1, Scavenger receptor class B type 1.