Table 1.
Patient characteristics, laboratory values at baseline and co-morbid disease conditions
|
Age ≥ 70 years |
Age < 70 to ≥ 60 years |
Age < 60 years |
p-value* | |
|---|---|---|---|---|
|
(n=1,373) |
(n=1,184) |
(n=1,253) |
||
| Median (IQR) or % | Median (IQR) or % | Median (IQR) or % | ||
| Age (years) |
74.0 (72.0-78.0) |
65.0 (62.0-67.0) |
54.0 (49.0-57.0) |
<0.0001 |
| Women (%) |
51.1 |
45.9 |
42.5 |
<0.0001 |
| Diabetes duration (years) |
6.8 (3.9-10.6) |
6.0 (3.3-9.5) |
4.1 (1.9-7.3) |
<0.0001 |
| Physically active (any sport) |
31.0 |
42.9 |
47.8 |
<0.0001 |
| Body Mass Index (kg/m2) |
29.0 (26.0-33.0) |
31.0 (28.0-35.0) |
32.0 (28.0-36.0) |
<0.0001 |
| Men (kg/m2) |
29.0 (26.0-32.0) |
30.0 (27.0-33.0) |
31.0 (28.0-36.0) |
<0.0001 |
| Women (kg/m2) |
30.0 (27.0-34.0) |
32.0 (28.0-36.0) |
33.0 (29.0-38.0) |
<0.0001 |
| Waist circumference (cm) |
104 (96.0-113.0) |
108 (98–117) |
109 (99.0-120.0) |
<0.0001 |
| HbA1c (%) |
7.3 (6.8-7.9) |
7.5 (6.9-8.4) |
7.6 (6.9-8.9) |
<0.0001 |
| Fasting plasma glucose (mmol/l) |
7.7 (6.4-9.2) |
7.8 (6.7-9.4) |
8.1 (6.8-10.1) |
<0.0001 |
| Postprandial plasma glucose (mmol/l) |
10.0 (8.6-11.8) |
10.2 (8.4-12.2) |
10.5 (8.7-13.0) |
<0.0001 |
| Co-morbidity |
|
|
|
|
| Dyslipidemia |
64.9 |
65.5 |
59.3 |
<0.01 |
| Hypertension |
90.5 |
86.2 |
76.0 |
<0.0001 |
| Coronary heart disease |
28.1 |
16.0 |
8.5 |
<0.0001 |
| Myocardial infarction |
28.8 |
37.0 |
50.0 |
<0.0001 |
| Stable angina |
33.6 |
26.2 |
20.0 |
<0.01 |
| Unstable angina |
3.2 |
3.8 |
5.1 |
0.40 |
| PCI |
35.2 |
44.1 |
52.5 |
<0.001 |
| Bypass surgery |
21.6 |
21.4 |
19.8 |
0.74 |
| Prior stroke / TIA |
6.8 |
4.3 |
2.5 |
<0.0001 |
| Heart failure |
18.6 |
7.5 |
2.6 |
<0.0001 |
| Peripheral arterial disease |
8.2 |
6.4 |
3.2 |
<0.0001 |
| Amputation |
1.3 |
0.6 |
0.8 |
0.16 |
| Autonomous neuropathy |
4.4 |
3.5 |
2.1 |
<0.01 |
| Peripheral neuropathy |
18.4 |
15.8 |
8.5 |
<0.0001 |
| NPDR |
5.2 |
3.5 |
2.4 |
<0.001 |
| Proliferative retinopathy | 1.0 | 0.4 | 0.1 | <0.01 |
Legend: HbA1c, glycosylated hemoglobin A1c; PCI, percutaneous coronary intervention; TIA, transitory ischemic attack; NPDR, non-proliferative retinopathy; * Cochran-Armitage or Jonchkheere-Terpstra test.