Figure 1.

Network map used to guide the assertion generation for an Intelligence Network relevant for the discovery of candidate biomarkers for AD. Assertions could be direct links between proteins/mRNAs and AD (and sub-types), or indirect links via gene mutations (e.g. for familial forms of AD, such as OMIM record #104300), via pathological processes (e.g. neuronal degeneration, amyloid formation, neurofibrillary tangles, hippocampal atrophy, tau deposition), or via anatomical structures (e.g. hippocampus, CA3 region, thalamus, temporal lobe). The relations (shown in blue) are examples of the vocabularies used in the assertions.