Table 1.

Sample vocabularies for key AD disease, pathological observations, and tissue concepts, used in the AD IN

Alzheimer's Disease sub-types	Pathological observations in AD	Brain regions affected in AD
Alzheimer's Disease	Acute-Phase Reaction	Amygdala
Early Onset Alzheimer's Disease	Amyloid Deposition	Anterior Thalamic Nucleus
Early Onset Familial Alzheimer's Disease	Amyloid Fibril Formation	Basal Nucleus of Meynert
Familial Alzheimer's Disease	Amyloidosis	CA1 region
Incipient Alzheimer's Disease	Asymmetric Cortical Atrophy	CA2 region
Late Onset Alzheimer's Disease	Blood Brain Barrier Dysfunction	CA3 region
Late Onset Sporadic Alzheimer's Disease	Central Nervous System Inflammation	Cholinergic Neuron
Mid-Stage Alzheimer's Disease	Cerebral Atrophy	Diagonal Band of Broca
Mild-to-Moderate Alzheimer's Disease	Cholinergic Dysfunction	Entorhinal Cortex
Moderate Alzheimer's Disease	Corpus Callosum Atrophy	Frontal Lobe
Moderate-to-Severe Alzheimer's Disease	Dystrophic Neuronal Growth	Hippocampus
Sporadic Alzheimer's Disease	Glial Inflammation	Inferior Temporal Gyrus
Severe Alzheimer's Disease	Gliosis	Left Thalamus
	Glucose Hypometabolism	Locus Coeruleus
	Granulovacuolar Degeneration	Medial Temporal Cortex
	Hippocampal Neurodegeneration	Parahippocampal Gyrus
	Inflammation	Parietal Lobe
	Locus Coeruleus Neuronal Loss	Prefrontal Cortex
	Mitochondrial Failure	Septal Nucleus
	Nerve Degeneration	Subiculum
	Neuritic Plaque Formation	Substantia Innominata
	Neurofibrillary Degeneration	Superior Temporal Gyrus
	Neurofibrillary Lesion	Synapse
	Neurofibrillary Tangle Formation	Temporal Isocortex
	Neuroinflammation	Temporal Lobe
	Neuronal Degeneration	Thalamus
	Neuronal Dysfunction
	Neuronal Dystrophy
	Neuronal Inclusion Bodies
	Neuronal Lesion
	Neuronal Loss
	Neuronal Necrosis
	Neuronal Shrinkage
	Occipital Atrophy
	Oxidative Damage
	Oxidative Stress
	Perivascular Amyloidosis
	Synapse Dysfunction
	Synaptic Degeneration
	Synaptic Loss
	Synapse Enlargement
	Tau Deposition
	Tau Phosphorylation
	Tau-Mediated Cytotoxicity