Table 3.
Anthropometric and metabolic variables and markers of endothelial function (n = 86)
| Baseline | E2 | E2+P | P | |
|---|---|---|---|---|
| Total-c (mg/dL) |
216 ± 31a |
207 ± 30b |
203 ± 32b |
< 0.01 |
| HDL-c (mg/dL) |
63 ± 16 |
61 ± 15 |
61 ± 15 |
0.06 |
| LDL-c (mg/dL) |
129 ± 29a |
123 ± 29a,b |
119 ± 28b |
< 0.01 |
| Triglycerides (mg/dL) |
120 ± 53 |
115 ± 51 |
111 ± 53 |
0.2 |
| Fast glucose (mg/dL) |
91 ± 11 |
91 ± 8 |
92 ± 11 |
0.2 |
| 2h glucose (mg/dL) |
103 ± 27 |
108 ± 36 |
105 ± 36 |
0.2 |
| Insulin (μU/mL) |
6.9 (3.9-9.7) |
6.2 (2.8 -8.8) |
6.9 (3.8 -9.1) |
0.2 |
| hsCRP (mg/L) | 1.51 (0.38-2.9) | 1.64 (0.4-3) | 1.19 (0.3-2.1) | 0.1 |
Values expressed as median and interquartile range or mean ± SD. P = two-way analysis of variance with repeated measures (non parametric variables were log-converted for statistical analysis and reconverted for presentation in table format).
Different superscript letters indicate statistical difference with Bonferroni multiple-comparison correction test (α < 5%).
Baseline: before hormone therapy; E2: estradiol only; E2+P estradiol + micronized progesterone.
HDL-c high-density lipoprotein cholesterol, hsCRP high-sensitivity C-reactive protein test, LDL-c low-density lipoprotein cholesterol, Total-c total lipoprotein cholesterol; 2h glucose: glucose levels 2 hours after 75g oral glucose load.