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Quantitative measurements of [11C]-MET tumor uptake (expressed in %ID/g). Uptake in MC7-L1 ER+ and ERαKD tumor-bearing mice was measured at days 0, 7, and 14 after the start of the treatment (control, n = 5 (a); fulvestrant, n = 5 (b); letrozole, n = 4 (c); tamoxifen, n = 5 (d). Asterisk denotes p < 0.05; double asterisk, p < 0.01; and triple asterisk, p < 0.005.
