Figure 6.

Summary of the results. In the basal state, PLCβ1 binds to TRAX, but on activation the complex dissociates, allowing PLCβ1 to catalyze PI(4,5)P₂ hydrolysis and downstream signaling events. PLCβ1 is also involved in TRAX-dependent RISC-mediated down-regulation of the metabolic proteins GAPDH and LDH. Down-regulation of these latter proteins eliminates H2B synthesis that ultimately leads to cell death. Alternately, PLCβ1 does not affect RNA interference of Hsp90, cyclophilin, or translin.