Table 1.
Bitter-tasting drugs and other bioactive compounds and their cognate human T2Rs
| Drug | Action | Responsive T2R isoforms | Ref. |
|---|---|---|---|
| Acetaminophen | Analgesic | 39 | 1 |
| Aloin | Laxative | 31, 43 | 1, 20 |
| Azathioprine | Immunosuppressive | 4, 10, 14, 46 | 1 |
| Carisoprodol | Muscle relaxant | 14, 46 | 1 |
| Chloramphenicol | Antibiotic | 1, 8, 10, 39, 43, 46 | 1 |
| Chloroquine | Antimalarial | 3, 7, 10, 39 | 1, 18 |
| Colchicine | Gout | 4, 39, 46 | 1 |
| Cromoglicic acid | Mast cell stabilizer | 7, 20, 43 | 1 |
| Dapsone | Topical Antibacterial | 4, 10, 40 | 1 |
| Dextromethorphan | Antitussive | 1, 10 | 1 |
| Diphenhydramine | Antihistamine | 14, 40 | 1 |
| Diphenidol | Antiemetic | 1, 4, 7, 10, 13, 14, 16, 20, 30, 31, 38, 39, 40, 43, 46 | 1 |
| Erythromycin | Antibiotic | 10 | 1 |
| Famotidine | Gastric acid Inhibitor | 10, 31 | 1 |
| Flufenamic acid | Anti-inflamatory | 14 | 1 |
| Haloperidol | Antipsychotic | 10, 14 | 1 |
| Hydrocortisone | Glucocorticoid | 46 | 1 |
| Methimazole | Antithyroid | 38 | 1 |
| Noscapine | Antitussive | 14 | 1 |
| Orphenadrine | Antispasmodic | 14, 46 | 1 |
| Papaverine | Antispasmodic | 7, 10, 14, 31,46 | 1, 18 |
| Pirenzapine | Gastric acid Inhibitor | 9 | 24 |
| Propylthiouracil | Antithyroid | 38 | 1, 3, 23 |
| Procainamide | Antiarrhythmic | 9 | 24 |
| Ofloxacin | Antibiotic | 9 | 24 |
| Quinine | Antimalarial | 4, 7, 10, 14, 31, 39, 40, 43, 46 | 1 |