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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Eur J Endocrinol. 2012 Feb 3;166(5):839–845. doi: 10.1530/EJE-11-1073

Figure 3.

Figure 3

Changes in serum free T4 levels from baseline (Δ) following the intravenous injection of 500 mcg of Thyrotropin-releasing hormone (TRH). Serum levels were measured at −15, 0, 5, 10, 15, 20, 30, 60, 120 and 180 minutes of TRH injection. Error bars represent the standard error of the mean at each time point. A: Data reported according to the −258A/G deiodinase type-2 genotype. Compared to −258A/A ancestral allele, carriers of the −258 G/x minor allele showed a significantly blunted TRH-stimulated increase in serum free T4 at 120' and at 180' after TRH injection. B: Data reported according to the −258/codon 92 haplotype. No significant differences were observed among haplotypes.