(A) Schematic of the CE-MALDI-MS fractionation apparatus. CE effluent is mixed with matrix before spotting on the MALDI target. (B) Schematic representation of the rotating ball inlet interface for continuous CE-MALDI-MS indicating (A) ball, (B) driveshaft, (C) Teflon gasket, (D) ISO-100 flange, (E) extraction lens, (F) matrix capillary, (G) buffer capillary, (H) anode and running buffer, (I) electrophoresis capillary, (J) cleaning solvent capillary, (K) felt pad and holder, and (L) solvent drain. CE effluent is continuously deposited with matrix on the rotating ball and desorbed using a laser. The ball is cleaned using solvent and a felt pad. Modified from refs. (A) [54] and (B) [61] with permission. ©2000 The Royal Society of Chemistry and © 2004 American Chemical Society, respectively.)