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. Author manuscript; available in PMC: 2012 Nov 29.
Published in final edited form as: Nat Med. 2011 Dec 18;18(1):159–165. doi: 10.1038/nm.2559

Figure 1. Ablation of neuronal Sirt1 exacerbates and over-expression of Sirt1 ameliorates phenotypes in R6/2 mouse.

Figure 1

(a) Latency to fall from accelerating rotarod at 10 weeks of age. n = 4 - 10 per group. *P < 0.05 for HD vs. BSKO-HD by ANOVA. (b) Striatal volumes at 20 weeks of age. n = 4 per group. *P < 0.01 by ANOVA. (c) Striatal neuronal volumes at 20 weeks of age. n = 4 per group. * P < 0.05 by t-test. (d) Aggregates of HTT in striata at 20 weeks of age. ** P < 0.01 (n=6 per group) (e) Survival of male HD (closed square) and Sirt1-KI-HD (open square) mice. n = 26 - 27 per group. P < 0.001 by log-rank test. (f) Striatal volume at 100 d of age. n = 5 – 6 per group. * P < 0.05 by ANOVA. (g) Striatal neuronal volumes at 100 d of age. n = 5 - 6 per group. *P < 0.05 by t-test. (h) Aggregates of HTT in striata at 100 d of age. ** P < 0.01 (n=7 per group).