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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Nat Neurosci. 2012 Nov 11;15(12):1736–1741. doi: 10.1038/nn.3257

Figure 2.

Figure 2

Structural equation model examining the moderating effect of gender on the mediation through childhood late afternoon basal cortisol of the association between early life stress and amygdala-vmPFC fcMRI. The SEM model demonstrated good fit: Chi2 = 1.89, p > 0.05; RMSEA = 0.00; SRMR = 0.03; CFI = 1.00. Paths are marked with unstandardized coefficients. Gender significantly moderated associations between ELS and childhood cortisol and childhood cortisol and amygdala-vmPFC fcMRI estimates and the mediating effect of childhood cortisol was marginally significant (Indirect Est. = −0.06, p = 0.09). In females only, higher levels of ELS predicted increased levels of childhood afternoon basal cortisol, which, in turn, predicted decreased amygdala-vmPFC functional connectivity. * p < 0.05, ** p < 0.01