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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Nat Neurosci. 2012 Nov 11;15(12):1736–1741. doi: 10.1038/nn.3257

Figure 3.

Figure 3

Structural equation model examining the moderating effect of gender on the mediation through amygdala-vmPFC fcMRI of the relation between childhood late afternoon basal cortisol and adolescent anxiety. The SEM model demonstrated good fit: Chi2 = 9.95, p > 0.05; RMSEA = 0.11; SRMR = 0.04; CFI = 0.94. Paths are marked with unstandardized coefficients. Gender only significantly moderated the association between childhood cortisol and amygdala-vmPFC fcMRI and the mediating effect of adolescent amygdala-vmPFC fcMRI was marginally significant (Indirect Est. = 0.13, p = 0.08). For females only, the developmental pathway between childhood cortisol and adolescent anxiety symptoms operates through inverse associations with adolescent amygdala-vmPFC fcMRI. * p < 0.05, ** p < 0.01