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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Gene Ther. 2012 Aug 23;20(4):444–449. doi: 10.1038/gt.2012.62

Figure 7.

Figure 7

GBM6 (A) or GBM12 (B) derived GSC were orthotopically implanted into the right caudate nucleus of nude mice. Animals were treated with a total dose of 1.8×106or 9×105 TCID50 MV-GFP, respectively, or UV inactivated virus. In both orthotopic treatment models, significant prolongation in survival was observed (p=0.0021 and p=0.0416 respectively). Abundant syncytia were observed in MV-GFP treated mice in H and E stain (C, E). Syncytia expressed the stem cell marker CD133 (D). Viral replication was confirmed by in situ hybridization for measles virus N mRNA (F).