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A) Frequency of IgG reactive with peptides corresponding to AQP4 extracellular loops (detected by ELISA). The statistical significance of comparisons among groups is presented (cutoff for significance p=<0.05). B) Illustrative results of western blot analyses using human AQP4 extracellular loop GST fusion proteins. C) Schematic representation of human AQP4 residues constituting extracellular loops A, C and E.
