Mean ± SE cumulative wheel revolutions run after 48-h food deprivation with 0-μg (n = 7), 1.25-μg (n = 7), 2.5-μg (n = 7), and 5-μg doses (n = 7) of central leptin for hamsters with no foraging requirement and a freely moving wheel (free wheel revolutions, top) and hamsters with a foraging requirement (foraging, bottom). *P < 0.05 compared with the food-deprived with 0 μg leptin control condition.