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. 2012 Nov 17;8(10):1420–1430. doi: 10.7150/ijbs.5273

Table 1.

Experimental approaches targeting CD28 signaling pathway using antagonistic CTLA-4-Ig.

Approaches (clone) condition Reported functions [references]
CTLA-4-Ig autoimmune disease Inhibited specific T cells activation 15
CTLA-4-Ig autoimmune disease Inhibited specific T cells activation 12, 13. Enhanced Treg function 14
CTLA-4-Ig+Anti-CTLA-4 mAb (9H10) transplantation Inhibited donor T cells proliferation 20. Depleted activated T cells 21
CTLA-4-Ig transplantation Prolonged allograft survival 46