Table 1.
Approaches (clone) | condition | Reported functions [references] |
---|---|---|
CTLA-4-Ig | autoimmune disease | Inhibited specific T cells activation 15 |
CTLA-4-Ig | autoimmune disease | Inhibited specific T cells activation 12, 13. Enhanced Treg function 14 |
CTLA-4-Ig+Anti-CTLA-4 mAb (9H10) | transplantation | Inhibited donor T cells proliferation 20. Depleted activated T cells 21 |
CTLA-4-Ig | transplantation | Prolonged allograft survival 46 |