Table 2.

Sources of noise and adversities in the movies.

Effect	How it is presented	Cause	Demonstrated
1. Image motion	Random frame-to-frame $x,y$, shifts	Patient motion, saccadic eye motion, camera movement	Fig. 5
2. Flicker	Random frame-to-frame brightness	Random changes of the lighting caused by patient motion, eye motion and camera movement	Some of the random fluctuations in Fig. 6 are from flicker
3. Wandering bright spot	The lighting is nonuniform, and its central bright spot wanders frame to frame	Vignetting that changes between frames due to patient motion, eye motion, and camera movement	Fig. 7
4. Quantum and electronic noise	Graininess in the image and time plots	Quantum photon noise and electronic noise of the SLO’s photodetector	Some of the fluctuations seen in Fig. 6 are from this effect
5. Cardiac pulsations	Low-frequency beats in the time plots	The dye fill is not smooth. It fills rhythmically with the cardiac cycle	Fig. 6
6. Background fluctuations	The black region becomes brighter and darker between frames and in the same frame	Stray and scattered light that changes when the patient, eye, or camera moves	Some of the random fluctuations in Fig. 6 are from this effect
7. Blinking	Black sections in a frame and completely black frames	Eye blinks	Not shown
8. Temporally truncated plot	The intensity curve stops before reaching a peak	Patient noncompliance or technician preference to stop the collection early	Not shown
9. Saturated pixels	The brightest regions of the plot are above the highest value detectable by the photodetector	Dynamic range of the SLO’s photodetector and its analog-to-digital converter	Not shown
10. Variation in injection administration	Rising slope of the curve varies from injection to injection	Inconsistent injection rate administered	Not shown