TABLE 1.
Properties of hippocampal pyramidal cells
Electrophysiology |
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---|---|---|---|
Reg. spiking | Bursting | p value | |
RN (MΩ) | 55.0 ± 3.1 | 33.7 ± 2.0 | < 0.001 |
Sag ratio | 0.84 ± 0.02 | 0.74 ± 0.02 | < 0.001 |
Subthreshold dV/dt (mV/mS) | 2.61 ± 0.53 | 4.39 ± 0.49 | < 0.001 |
ADP amplitude (mV) | 17.9 ± 1.3 | 22.2 ± 0.9 | < 0.001 |
2nd spike threshold (mV) | −40.8 ± 0.7 | −45.1 ± 0.9 | < 0.001 |
Max 2nd falling dV/dt (mV/ms) | −56 ± 3 | −65 ± 3 | < 0.01 |
Max 2nd rising dV/dt (mV/ms) | 240 ± 24 | 272 ± 22 | < 0.05 |
1st spike FWHM (ms) | 0.87 ± 0.01 | 0.82 ± 0.02 | < 0.05 |
Resting membrane potential (mV) | −65.8 ± 0.7 | −66.2 ± 0.4 | n.s. |
1st spike threshold (mV) | −53.1 ± 1.0 | −52.4 ± 0.6 | n.s. |
Max 1st spike rising dV/dt (mV/ms) | 460 ± 21 | 488 ± 21 | n.s. |
Max 1st spike falling dV/dt (mV/ms) | −106 ± 4 | −113 ± 5 | n.s. |
2nd spike FWHM (ms) | 1.18 ± 0.03 | 1.14 ± 0.04 | n.s. |
1st spike height (mV) | 92.0 ± 1.5 | 90.3 ± 1.6 | n.s. |
2nd spike height (mV) | 71.3 ± 3.0 | 70.0 ± 2.3 | n.s. |
AHP amplitude (mV) | −1.29 ± 0.25 | −1.39 ± 0.31 | n.s. |
Morphology |
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Reg. spiking | Bursting | p value | |
Total tuft dendrite length (mm) | 1.39 ± 0.02 | 1.49 ± 0.03 | < 0.01 |
Total basal dendrite length (mm) | 3.89 ± 0.26 | 3.08 ± 0.17 | < 0.01 |
Basal branching order | 4.40 ± 0.26 | 3.29 ± 0.23 | < 0.01 |
Distance to main bifurcation (µm) | 193.8 ± 19.3 | 264.4 ± 22.8 | < 0.05 |
Basal branch points | 50.1 ± 3.8 | 40.9 ± 3.1 | < 0.05 |
Tuft branch points | 33.7 ± 2.8 | 41.6 ± 3.3 | < 0.05 |
Apical branching order | 4.91 ± 0.72 | 7.93 ± 1.48 | < 0.05 |
Proximal apical dendrite length (mm) | 1.76 ± 0.21 | 1.35 ± 0.14 | n.s. |
Middle apical dendrite length (mm) | 1.67 ± 0.28 | 1.48 ± 0.16 | n.s. |
Proximal apical branching order | 5.53 ± 0.47 | 4.98 ± 0.36 | n.s. |
Middle apical branching order | 4.81 ± 0.32 | 4.16 ± 0.40 | n.s. |
Proximal apical branch points | 25.0 ± 3.4 | 28.0 ± 2.6 | n.s. |
Middle apical branch points | 33.7 ± 1.9 | 34.6 ± 3.2 | n.s. |
Basal branches off soma | 3.90 ± 0.47 | 3.65 ± 0.39 | n.s. |
Mean ± S.E.M. for all values. Electrophysiology, n = 268; Morphology, n = 110