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. Author manuscript; available in PMC: 2013 Nov 21.
Published in final edited form as: Cell. 2012 Nov 21;151(5):1113–1125. doi: 10.1016/j.cell.2012.10.024

Figure 3. GR43a functions as a fructose sensor in the brain.

Figure 3

(A) Brain neuron expressing G-CaMP3.0 under control of Gr43aGAL4: ΔF pseudocolor fluorescence image was taken 24 seconds after application of 100mM fructose (right).

(B)Gr43aGAL4 neurons specifically respond to fructose. Max ΔF/F within 15 minutes of application is shown. All sugars are 100 mM. Flies contained two genomic copies of Gr43a. **p < 0.0001; ANOVA. Error bars represent standard error. 6≤n≤7.

(C) Response of Gr43aGAL4 neurons to fructose is dose- and Gr43a dependent. **p < 0.0001; ANOVA. Error bars represent standard error. 8≤n≤9.

(D) Time-course of G-CaMP3.0 fluorescence changes in Gr43aGAL4 neurons stimulated with different concentrations of fructose.