Figure 2.

(a) IRF5 gene marked with previously reported functional variants along with studied SNPs [64]. The first three grey boxes represent differentially spliced first exons (1A, 1B, and 1C), the next light blue boxes represent the exons 2–9, and the last black box indicates the 3′ UTR. SNPs rs2280714 and rs10488631 were used as proxies for rs10954213 in the 3′ UTR due to high LD. (b) IRF5 mRNA isoforms [22]. There are eleven different variants. PEST, proline-, glutamic acid-, serine-, and threonine-rich.