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. 2012 Nov 20;3(6):e00224-11. doi: 10.1128/mBio.00224-11

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Copyright © 2012 Bachman et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

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FIG 4 — The perivascular spaces contain serum exudate as indicated by transferrin. Merged immunofluorescence images of formalin-fixed paraffin-embedded histological sections of lungs from Lcn2^+/+ (A) or Lcn2^−/− (B) mice 3 days after retropharyngeal inoculation of 1 × 10⁴ CFU/ml of K. pneumoniae siderophore mutants, stained using antitransferrin rabbit polyclonal IgG (Tf) (red) and the nucleic acid stain DAPI (blue), are shown. Magnified merged and DAPI-only images (C) of insets from Lcn2^−/− mice in panel B demonstrate nuclei (N) and collections of bacteria (representative bacilli are indicated by arrowheads) in the perivascular space. Merged images of Lcn2^−/− mice mock infected with PBS (D) or infected with iroA mutant K. pneumoniae but lacking antitransferrin antibody (E) are shown as controls. Magnification, ×400, except panel C (×4,000); V, vessels.